Vice Report: Wearable Ketamine ?

An interesting report from Vice about Californian company Bexson Biomedical who are working on develpping a wearable device (think insulin) that delivers ketamine directly to the patient as a way of combatting opioid addiction.


Vice write..

Bexson Biomedical, a California-based company, is already in the process of making such a device. Here’s how it works, in theory: wearable ketamine will be a Bluetooth-controlled device that you can stick on your skin, most likely your belly area. The device will contain a disposable cartridge filled with liquid ketamine, which is injected via a tiny needle into the layer of fat between your skin and muscle. 


Bexson Biomedical’s biggest bet—and what it is pitching to its investors—is that wearable ketamine will chip away at the US opioid crisis, a grim epidemic that has been raging for the past two decades and shows no signs of abating. According to the CDC, opiate overdoses claimed 50,042 lives in 2019, with over 40% of deaths involving a prescription opioid like oxycontin. In comparison, ketamine is a powerful pain reliever that has been used as an anesthetic since the 1960s, and there is some evidence that low-dose ketamine is as effective as opiates like morphine for controlling acute pain.

Read the full report at


From the. website



The FDA first approved ketamine in 1970 for anesthesia. It was added to the World Health Organization’s Model List of Essential Medicines in 1985. In 2019 a pure S-enantiomer variant of ketamine was approved for intranasal delivery in treatment of Major Depression. Ketamine is a novel and powerfully effective pain reliever, with research establishing efficacy across a broad range of pain types (e.g., neuropathic, inflammatory, nociceptive). Effects upon pain are synergistic and diverse.3,4 They are proven equal to or better than strong opioid and opiate medications, including methadone, meperidine, fentanyl and morphine.5,6,7,8,9,10,11 Ketamine’s distinct pharmacodynamic properties allow reliable reduction of opioid use in pain management.16,17,18,19 Indeed, pain status improves with ketamine over time rather than worsening,20,21 likely due to reversal of hyperalgesic forces that often transform acute pain into chronic pain conditions. Increased pain signaling commonly results from opioid medications, a disturbing byproduct of current pain management techniques.22 Ketamine’s potential is notable, with dozens of studies demonstrating efficacy in pain conditions and safety data established through decades of available data on patients ages 8 to 93.



While ketamine has remarkable therapeutic potential, its utility is limited by its short half-life and low-bioavailability when taken orally or intranasally.  Bexson’s subcutaneous delivery solution with a wearable and minimally invasive patch pump allows of continuous release at therapeutically relevant doses.  The company’s proprietary formulation, BB106, has the solubility and chemical properties that allow for subcutaneous delivery.

Ketamine vs Opioids for pain relief by Bexson Biomedical | Ketamine Reformulation

Pain relief is achieved at low doses compared to depression

Existing research has established substantial pain relief with ketamine dosing that is substantially lower than those often used to treat depression.  Lower dosing translates to fewer side effects and increased safety in population-wide assessment.

Key Opinion Leaders in pain management confirm the need for Bexson’s technology

Ketamine is already used to great effect by pain physicians, but delivery limitations hamper broader solutions. Key opinion leaders in pain management express notable enthusiasm and interest in Bexson’s new low-dose subcutaneous ketamine delivery platform.

The Opioid Public Health Emergency in pain management demands answers

The misery and death associated with the national opioid crisis mandates safer treatments with effect size large enough to replace opioids. No other medicine can offer this except ketamine. Physicians need new treatment options, the FDA is motivated to review new therapies, and payers will reimburse new alternatives.

Multiple conditions can benefit from Bexson’s ketamine platform

Numerous ICD-10 pain conditions would benefit from a ketamine delivery system capable of controlled, low dose infusions outside the clinic or hospital. Research shows ketamine can treat the following conditions:

  • Post Laminectomy Syndrome & Failed Back Syndrome

  • Acute Post-Operative Pain

  • Acute and Chronic Migraine

  • Neuropathic Pain from Spinal Cord Injury

  • Fibromyalgia & Diffuse Connective Tissue Disease

  • Cervical Spine Trauma

  • Pain due to Nerve Injury

  • Chronic and Traumatic Neuropathy

  • Ischemic Limb Pain

  • Mechanical Allodynia

  • Post Herpetic Neuralgia

  • Trigeminal Neuralgia


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